In order to solve the problems of a large number of pressure measurement equipment that needs to be calibrated, the scattered range, and the special and diverse kinds of media in the aircraft ground tests, this paper makes a theoretical analysis on the calibration principle and method of pressure measurement equipment, and designs an integrated pressure calibration device with multi?channel, multi?range and multi?media. The system has the functions of automatic control, acquisition and data processing. The calibration requirement of pressure measurement equipment for aircraft ground test has been practically solved, the calibration efficiency has been improved, and the application effect has been achieved.