Aiming at the requirement of dynamic calibration of pressure sensor in low temperature environment, the paper designs a sine pressure generator with bellows as the core components. The sine pressure generator has good tightness at either room temperature or low temperature and it can generates pressure ranging from positive to negative. Based on the adjustment of the structural parameters of the sine pressure generator and the further test, followed by the theoretical analysis of the experimental data, the empirical formula for calculating the amplitude of sine pressure is obtained. The feasibility of bellows as sine pressure generator is proved.