At present, there are some problems in the field of simulation calculation of the high altitude cabin exhaust system, such as the time-consuming of geometric modeling and the slow process of simulation. In order to solve these problems, according to the characteristic of the typical geometry structure of the high altitude cabin exhaust system, the parametric modeling scheme is adopted in this paper, the geometric model of the high altitude cabin exhaust system is formed by combining the parameterized models of the foundation structure. Through automatic grid division and numerical calculation of the geometric model of the exhaust system of the altitude cabin, the flow field and temperature field distribution data of the exhaust system of the altitude cabin are obtained, and are verified by comparison with the test results, the results show that the relative error between the calculated results and the test results is less than 3% , which meets the requirements of engineering practice. On this basis, advanced computer software development technology is adopted to package and customize the above analysis process, and combined with the secondary development technology of commercial software, finally, a parameterized simulation software package platform for the high altitude cabin exhaust system is formed. With this platform, a parameterized model of the high altitude cabin exhaust system can be built quickly, and the whole process of the exhaust system can be simulated quickly，and it has the advantages of high efficiency, convenience, accuracy, etc.