With the deepening of enterprise reform and the development of information technology, the informationization is necessary for modern enterprises to participate in market competition. The informationization of measurement management system is an important part of enterprise information construction. Combined with the characteristics of the metrological work of enterprises and institutions, the paper puts forward and establishes the informatization solutions of measurement management system that meets the demands. On the basis of the laboratory management handbook and program files, the resource management, measurement equipment management, system operation management, data management, and other elements are brought into the informatization of the measurement management system and dynamic management is implemented to provide timely and efficient measurement assurance support for the enterprise. At the same time, it is of certain reference value for improving the information construction of metrological management to discuss the expected application effect.