In the firing of rockets and missiles, the accelerometer used to measure the vibration of the launch device may suffer impacts by the high-speed airflow. In order to explore the effects of high-speed airflow on acceleration measurement, this paper introduces the protecting treatment and the measurement results in laboratory and field test. In laboratory test, the compressed air was used to simulate the blowing of the high-speed air flow, and the acceleration signal of a naked accelerometer was compared with that of the shielded accelerometer. With the laboratory and the subsequent field test, it is concluded that the accelerometer under the high-speed air flow must be protected with proper shield devices. The conclusion provides some useful and meaningful references for acceleration measurement under similar circumstances.