In order to solve the problems of large machining deformation and poor milling stability in the manufacturing process of thin-walled curved torsional transonic blade profile of titanium alloy blisk, a pre deformation control method for machining integral blisk is proposed in this paper. The position degree and twist angle of blade profile are obtained by 3D profile detection technology, and the bending and torsion deformation of blade are controlled by reverse compensation method of profile milling deformation error. The results show that the method can effectively improve the machining accuracy and the qualified rate of finished products.