In this paper, the vibration suppression of cantilever beam support system under strong flow field is studied, and a set of vibration suppressor system is designed using piezoelectric ceramic as actuator based on the actual vibration condition of the model support system in transonic facility. The model support sting is designed, and the axial and circumferential installation positions of the active vibration damper are optimized to obtain the best output performance of the active vibration damper. Based on the PD control algorithm, a laboratory simulation system is set up, and the excitations with acceleration amplitudes of 0.5g, 1.3g, and 2g are applied to the free end of the model. The experimental results show that the residual amplitude ratios are 12%, 10%, and 26%. A good vibration suppression effect is achieved.