In the wind tunnel calibration test of air temperature sensor, due to the high-test cost and the gap between the calibration test environment and the actual use environment, it is necessary to build the virtual wind tunnel for the numerical calibration of the air temperature sensor, and realize the error correction and virtual calibration of the air temperature sensor under the extremely abnormal calibration condition. The virtual calibration of the numerical wind tunnel of the air temperature sensor is obtained. The simulation results can lower the working conditions of the real calibration as much as possible, and provide a supplement for the design and calibration of the air temperature sensor from the theoretical level. The development of air temperature calibration at home and abroad is introduced. The realization idea and method of virtual wind tunnel for the numerical calibration of air temperature sensor are analyzed. How to establish virtual simulation wind tunnel on computer platform by Computational Fluid Dynamics (CFD) technology is discussed to simulate the real calibration environment, which provides technical reference for the establishment of the virtual wind tunnel for the numerical calibration of domestic air temperature sensor.