Due to many factors in the test site, the calibration coefficient of multi-dimensional force sensor in laboratory has not been applied to the liquid rocket engine test site. The in-situ calibration method for the liquid rocket engine multi-dimensional force measurement device is studied in the paper. The influence factors of vacuum environment, pipeline binding force and temperature drift are also analyzed. The results show that the calibration method can effectively reduce the uncertainty of the multi-dimensional force measuring device, and provide a reference for the in-situ calibration in the field of multi-dimensional force measurement.