With the development of the aviation technology, it is necessary to construct a supersonic calibration wind tunnel which meets the needs of dynamic calibration of sensors. A measurement and control system for sensor calibration using in supersonic calibration wind tunnel has been designed based on TCP/IP protocol and LabVIEW. The theory of operation, structure of hardware and design of software has been explained. Through the system operation and performance testing, the system has the capacity of data communication and remote control, and meets the requirements of the calibrating testing in supersonic air.